IL-17A deficiency alleviates PM-induced allergic asthma by suppressing Th17 cell secretion cytokines and mucus overproduction

Abstract Particulate matter (PM) aggravates airway and lung inflammatory response in allergic asthma by directly inducing Th17 cells to secrete cell-associated factors chemokines. IL-17A is a key cell secretion pro-inflammatory cytokine. In this study, we investigated the role of PM-induced mice. 7–8 weeks old wild type (WT) mice, similarly knockout (KO) were divided into four experimental groups (healthy control, PM only, OVA OVA+PM treatment groups) treated accordingly. Inflammatory eosinophil infiltration increased WT mice compared healthy but decreased KO Among toll-like receptors (TLRs) that play an important innate immune response, TLR2/4/7 expression was significantly reduced Furthermore, observed decrease mRNA IL-13, IL-17A, IL-22, TGF-β among cytokines Th2 facilitated overt histopathological symptoms such as mucus overproduction goblet hyperplasia while showed mitigated responses These results prove plays pathogenesis asthma. This research funded Ministry Education. Education